Yayın tarihi için Moleküler Biyoloji ve Genetik Bölümü Makale Koleksiyonu listeleme
Toplam kayıt 59, listelenen: 21-40
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HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions
(Springer, 2021)Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus. Functional characterization of mutant proteins reveals ... -
Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study
(TUBITAK, 2021)The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ... -
Synthesis, Characterization and Biocompatibility Oo Plant-Oil Based Hydrogels
(Trakya University, 2021)Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel ... -
Observation of the doubly Cabibbo-suppressed decays D + → K + π 0 π 0 and D + → K + π 0 η
(Springer Science and Business Media Deutschland GmbH, 2022)By analyzing e+e− annihilation data corresponding to an integrated luminosity of 2.93 fb−1 collected at the center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first observations of the doubly ... -
Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source
(Nature Research, 2023)High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations ... -
Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
(WILEY-V C H VERLAG GMBH, 2023)Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid ... -
In Vitro and Molecular Docking Evaluation of Larvicidal Effects of Essential Oils of Five Aromatic Plants on the Fall Armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast
(WILEY-V C H VERLAG GMBH, 2023)Faced with the serious consequences resulting from the abusive and repeated use of synthetic chemicals, today rethinking crop protection is more than necessary. It is in this context that the essential oils of the Lamiaceae ... -
Phenolic compounds as histone deacetylase inhibitors: binding propensity and interaction insights from molecular docking and dynamics simulations
(SPRINGER WIEN, 2023)Histone deacetylases are well-established target enzymes involved in the pathology of different diseases including cancer and neurodegenerative disorders. The approved HDAC inhibitor drugs are associated with cellular ... -
Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches
(WILEY-V C H VERLAG GMBH, 2023)Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ... -
Expression of genes related to iron homeostasis in breast cancer
(SPRINGER, 2023)Background The dysfunctions in the metabolism of iron have an important role in many pathological conditions, ranging from disease with iron deposition to cancer. Studies on malignant diseases of the breast reported irregular ... -
Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches
(MDPI, 2023)Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. ... -
In the quest for histone deacetylase inhibitors: current trends in the application of multilayered computational methods
(SPRINGER WIEN, 2023)Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades because of their potential in the treatment of different diseases including various forms of cancers, neurodegenerative disorders, ... -
Comparative GC-MS Analysis of Fresh and Dried Curcuma Essential Oils with Insights into Their Antioxidant and Enzyme Inhibitory Activities
(MDPI, 2023)Species belonging to the Zingiberaceae family are of high nutritional, industrial, and medicinal values. In this study, we investigated the effect of processing steps (fresh vs. dried milled rhizomes) and extraction ... -
A comparative study on chemical profiles and biological activities of different extracts of three Verbascum species from Turkey
(ELSEVIER, 2023)The present study aimed to evaluate the antioxidant and enzyme inhibition properties of aerial part of Verbascum cheiranthifolium Boiss. V. myriocarpum Boiss. & Heldr. and V. pyroliforme (Boiss. & Heldr.) Kuntze as well ... -
LC-MS/MS and GC-MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus HAUSSKN. & VELEN. extracts
(WILEY-V C H VERLAG GMBH, 2023)The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were ... -
Appraisals on the chemical characterization and biological potentials of Ranunculus constantinopolitanus extracts using chromatographic, computational, and molecular network approaches
(Elsevier Ltd, 2023)In this context, phytochemicals were extracted from Ranunculus constantinopolitanus using ethyl acetate (EA), ethanol, ethanol/water (70%), and water solvent. The analysis encompassed quantification of total phenolic and ... -
Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2-treated HDF cells of the extracts of Stachys tundjeliensis
(John Wiley and Sons Inc, 2023)The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts ... -
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies
(John Wiley and Sons Inc, 2023)Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have been few studies investigating the phytochemistry and biological properties of these plants has not been investigated. The aim of this ... -
Comparative Study on the Chemical Profile, Antioxidant Activity, and Enzyme Inhibition Capacity of Red and White Hibiscus sabdariffa Variety Calyces
(American Chemical Society, 2023)Hibiscus sabdariffa L. (Family: Malvaceae) is believed to be domesticated by the people of western Sudan sometime before 4000 BC for their nutritional and medicinal properties. This study aimed to investigate the chemical ... -
Chemical characterization of Glaucosciadum cordifolium extracts obtained by different extraction techniques and their biopharmaceutical effects
(Elsevier Ltd, 2023)Glaucosciadium cordifolium (Apiaceae) is traditionally used against stomach ailments, as aphrodisiac and appetizer. This study endeavored to characterize several extracts of G. cordifolium aerial parts (prepared by various ...