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dc.contributor.authorUsanmaz, Hande
dc.contributor.authorTas, Omer
dc.contributor.authorEkinci, Deniz
dc.contributor.authorUba, Abdullahi Ibrahim
dc.contributor.authorAtmaca, Ufuk
dc.date.accessioned2024-07-03T10:11:01Z
dc.date.available2024-07-03T10:11:01Z
dc.date.issued2024en_US
dc.identifier.citationUsanmaz, H., Taş, Ö., Ekinci, D., Uba, A. I., & Atmaca, U. (2024). Biological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase. Future Medicinal Chemistry, 1-11.en_US
dc.identifier.issn17568919
dc.identifier.urihttps://doi.org/10.1080/17568919.2024.2342641
dc.identifier.urihttps://hdl.handle.net/20.500.12294/4124
dc.description.abstractAim: A highly efficient one-step method has been developed for the synthesis of benzofuranyl derivatives from 2-benzoylcyclohexane-1-carboxylic acid derivatives using chlorosulfonyl isocyanate. This novel method provides a practical, cost-effective and efficient approach. Materials & methods: The inhibitory effects of benzofuranyl derivatives on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. Ki values were determined to range from 0.009 to 0.61 mu M for AChE and 0.28 to 1.60 mu M for BChE. Molecular docking analysis provided insights into the interaction modes and binding patterns of these compounds with AChE and BChE. Conclusion: Kinetic findings of our study suggest that some of our compounds exhibited more effective low micromolar inhibition compared with the reference, and these derivatives could be to design more powerful agents.en_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofFUTURE MEDICINAL CHEMISTRYen_US
dc.identifier.doi10.1080/17568919.2024.2342641en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCATALYZED CARBONYLATIVE CYCLIZATIONen_US
dc.subjectENZYMEen_US
dc.subjectACIDSen_US
dc.titleBiological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesteraseen_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.authorid0000-0002-0853-108Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorUba, Abdullahi Ibrahim
dc.authorwosidP-3971-2019en_US
dc.authorscopusid57038704300en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.wosWOS:001236934400001en_US
dc.identifier.scopus2-s2.0-85194750186en_US
dc.identifier.pmid38916565en_US


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