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dc.contributor.authorBayramova, Jamila
dc.contributor.authorTarakci, Elif
dc.contributor.authorHuseynova, Gumru
dc.contributor.authorYazici, Hilal
dc.contributor.authorYazici, Hulya
dc.date.accessioned2024-07-03T07:25:27Z
dc.date.available2024-07-03T07:25:27Z
dc.date.issued2024en_US
dc.identifier.citationBAYRAMOVA, J., TARAKCI, E., HUSEYNOVA, G., YAZICI, H., & YAZICI, H. (2024). Genetic Alterations in Lung Cancer. TURKISH JOURNAL OF ONCOLOGY, 1(1).en_US
dc.identifier.issn13007467
dc.identifier.urihttps://doi.org/10.5505/tjo.2024.4285
dc.identifier.urihttps://hdl.handle.net/20.500.12294/4114
dc.description.abstractLung cancer is the leading cause of cancer -related deaths worldwide. Due to the prevalence of late -stage diagnoses, treatment options are frequently constrained. Molecular profiling of lung cancer is crucial for the clinical management and successful therapy of the disease because lung cancer originates from a multilayered carcinogenesis consisting of multiple genetic and epigenetic abnormalities. The potential of anomalies involved in carcinogenesis as biomarkers that can be used in the diagnosis and treatment of lung cancer has begun to be evaluated due to the development of new generation sequencing methods and their more frequent application in the clinic. This review presents information regarding the genetic alterations responsible for the malignant transformation of lung cells. The article highlights the predominant gene mutations that are specific to a particular subtype of lung cancer, their impact on the clinical progression of the disease, and the response to treatment. However, in summarizing all genetic features, the latest information from the NCCN v2.2024 guide was taken into account.en_US
dc.language.isoengen_US
dc.publisherKARE PUBLen_US
dc.relation.ispartofTURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGYen_US
dc.identifier.doi10.5505/tjo.2024.4285en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDRIVER MUTATIONSen_US
dc.subjectRECENT PROGRESSen_US
dc.subjectADENOCARCINOMAen_US
dc.subjectCLASSIFICATIONen_US
dc.subjectINHIBITIONen_US
dc.subjectSUBTYPESen_US
dc.subjectTHERAPYen_US
dc.subjectBIOLOGYen_US
dc.subjectIMPACTen_US
dc.subjectNSCLCen_US
dc.titleGenetic Alterations in Lung Canceren_US
dc.typearticleen_US
dc.departmentTıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.authorid0000-0002-8919-0482en_US
dc.identifier.volume39en_US
dc.identifier.issue2en_US
dc.identifier.startpage234en_US
dc.identifier.endpage243en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorYazici, Hulya
dc.authorwosidGSK-8744-2022en_US
dc.authorscopusid7102511789en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.wosWOS:001251175600006en_US
dc.identifier.scopus2-s2.0-85196362709en_US


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