https://hdl.handle.net/20.500.12294/242 Psikoloji Bölümüne ait koleksiyonlar bu alt bölümde listelenir. Tue, 14 Apr 2026 14:28:11 GMT 2026-04-14T14:28:11Z https://hdl.handle.net/20.500.12294/4111 Exome data of developmental and epileptic encephalopathy patients reveals de novo and inherited pathologic variants in epilepsy-associated genes Capan, Ozlem Yalcin; Yapici, Zuhal; Ozbil, Mehmet; Caglayan, Hande S. Purpose: In Developmental and Epileptic Encephalopathies (DEEs), identifying the precise genetic factors guides the clinicians to apply the most appropriate treatment for the patient. Due to high locus heterogeneity, WES analysis is a promising approach for the genetic diagnosis of DEE. Therefore, the aim of the present study is to evaluate the utility of WES in the diagnosis and treatment of DEE patients. Methods: The exome data of 29 DEE patients were filtrated for destructive and missense mutations in 1896 epilepsy-related genes to detect the causative variants and examine the genotype-phenotype correlations. We performed Sanger sequencing with the available DNA samples to follow the co-segregation of the variants with the disease phenotype in the families. Also, the structural effects of p.Asn1053Ser, p.Pro120Ser and p. Glu1868Gly mutations on KCNMA1, NPC2, and SCN2A proteins, respectively, were evaluated by molecular dynamics (MD) and molecular docking simulations. Results: Out of 29, nine patients (31%) harbor pathological (P) or likely pathological (LP) mutations in SCN2A, KCNQ2, ATP1A2, KCNMA1, and MECP2 genes, and three patients have VUS variants (10%) in SCN1A and SCN2A genes. Sanger sequencing results indicated that three of the patients have de novo mutations while eight of them carry paternally and/or maternally inherited causative variants. MD and molecular docking simulations supported the destructive effects of the mutations on KCNMA1, NPC2, and SCN2A protein structures. Conclusion: Herein we demonstrated the effectiveness of WES for DEE with high locus heterogeneity. Identification of the genetic etiology guided the clinicians to adjust the proper treatment for the patients. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4111 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4109 Investigation of the role of difficulty in emotion regulation in the relationship between attachment styles and binge eating disorder Bekmezci, Zehra; Cagatay, Safiye Elif Attachment and emotion regulation affect various aspects of an individual's life throughout the lifespan and into adulthood, and are known to be associated with various psychopathologies. Based on a review of the literature, attachment styles and the management of negative emotions have a significant role in the development and maintenance of Binge Eating Disorder (BED). Previous studies have found that insecure attachment styles increase the risk of developing BED, but the role of emotion regulation difficulties has not been assessed. The aim of the current study is to examine the role of emotion regulation difficulties in the relationship between insecure attachment styles and symptoms of BED. The sample of the current study consisted of 364 participants (238 females, 126 males) aged 18-65 years (M = 35.27, SD = 10.00) residing in different provinces of Turkey. Sociodemographic information form, Binge Eating Disorder Scale (BEDS), Difficulty in Emotion Regulation Scale-Short Form (DERS-16), and Inventory of Experiences in Close Relationships-2 were administered to the participants. The results of the present study showed that difficulties in emotion regulation played a mediating role in the relationship between symptoms of BED and avoidant and anxious attachment styles. The results of the current study highlight the importance of clinicians assessing attachment styles and emotion regulation difficulties, examining the interaction of these variables together, and providing interventions accordingly when faced with symptoms of BED. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4109 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4084 Childhood traumas and emotional eating Kocak, Zeynep; Cagatay, Safiye Elif Emotional eating is a very multi-dimensional behavior that involves consuming food in response to emotional triggers such as stress, sadness or happiness. It is also known that this behavior can arise from stressful events in childhood. Childhood trauma can cause various psychopathologies by affecting the emotional processes of individuals throughout their lives. Traumatic life events, low self-esteem and coping with negative emotions may play a role in the development and maintenance of emotional eating behaviour, which may manifest as an emotional response. Although there are studies in the literature that consider these variables separately, there is no study that evaluates these variables as a whole. The aim of the current study is to examine the role of self-esteem and emotion dysregulation in the relationship between childhood trauma and emotional eating behaviour. The sample of the study consisted of 400 participants (260 females, 140 males) in the age group of 24-50 years (M = 42.00, SD = 6.91) residing in different provinces of Turkey. Sociodemographic information form, Childhood Trauma Questionnaire (CTQ), Difficulty in Emotion Regulation Scale (DERS), Rosenberg Self-Esteem Scale (RSES) were administered to the participants. In the current study, the mediating role of self-esteem and emotion dysregulation in the relationship between childhood traumas and emotional eating behavior was tested with 2 different models in SPSS 29 software with PROCESS plug-in. The results of the study revealed that childhood traumas predicted emotional eating behavior and emotion dysregulation. In addition, childhood traumas and emotional eating behavior were found to negatively predict self-esteem. In this context, it was seen that emotional eating behavior revealed emotion dysregulation. When the mediation analysis results were analyzed, it was seen that similar results emerged. The results of the current study showed that emotion dysregulation and self-esteem mediated the relationship between childhood trauma and emotional eating behaviour. Childhood traumas negatively predicted self-esteem, while low self-esteem led to emotional eating behavior. Similarly, it was found that individuals who experienced childhood traumas had emotion dysregulation and emotional eating behavior. The results of the present study highlight the importance for clinicians to assess childhood experiences, emotion regulation processes and self-esteem levels, to consider these variables together, and to provide cognitive and behavioural interventions when emotional eating is identified. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4084 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4013 Investigation of PTSD and Psychopathological Symptoms in Substance Users Bulus, Seyma); Cakici, Mehmet; Kuzgun, Tubanur Bayram Konferans öğesi Sun, 01 Jan 2023 00:00:00 GMT https://hdl.handle.net/20.500.12294/4013 2023-01-01T00:00:00Z